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Page 1
SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics.
Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13330-13339. doi: 10.1073/pnas.1902658116. Epub 2019 Jun 18.
Proc Natl Acad Sci U S A. 2019.
PMID: 31213532
Free PMC article.
SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers.
Jones GG, Del Río IB, Sari S, Sekerim A, Young LC, Hartig N, Areso Zubiaur I, El-Bahrawy MA, Hynds RE, Lei W, Molina-Arcas M, Downward J, Rodriguez-Viciana P.
Jones GG, et al.
Nat Commun. 2019 Jun 10;10(1):2532. doi: 10.1038/s41467-019-10367-x.
Nat Commun. 2019.
PMID: 31182717
Free PMC article.
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SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis.
Young LC, Hartig N, Boned Del Río I, Sari S, Ringham-Terry B, Wainwright JR, Jones GG, McCormick F, Rodriguez-Viciana P.
Young LC, et al. Among authors: jones gg.
Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10576-E10585. doi: 10.1073/pnas.1720352115. Epub 2018 Oct 22.
Proc Natl Acad Sci U S A. 2018.
PMID: 30348783
Free PMC article.
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The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding.
Beggs JE, Tian S, Jones GG, Xie J, Iadevaia V, Jenei V, Thomas G, Proud CG.
Beggs JE, et al. Among authors: jones gg.
Biochem J. 2015 Apr 1;467(1):63-76. doi: 10.1042/BJ20141066.
Biochem J. 2015.
PMID: 25588502
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